Emphasis on the CIS syllabi: It’s wise to emphasize that this Curriculum/syllabus is tentative & the subject’s distribution or teaching hours or exams might vary in different universities and CIS.
Brief description of the course
Pharmacology is a multidisciplinary science, uniting data of theoretical sciences with clinical practice, especially pharmacotherapy. Value of pharmacological researches that they allow to reveal mechanisms of action of drugs and to study the influence of pharmacotherapy on all organisms.
Pharmacology is obligatory for medical students to understand the influence and interaction of medicinal substances in the body. Knowledge of bases of pharmacotherapy is absolutely necessary for the doctor of any specialty.
General pharmacology: Introduction to pharmacology. Content, subject, methods of investigation in pharmacology. Association of pharmacology with other disciplines. General receipts.
System pharmacology. Neurotropic drugs. Drugs affecting on the peripheral nervous system. Drugs affecting afferent innervation. Drugs affecting efferent innervation. Drugs affecting the central nervous system. Drugs affecting inflammation and allergy. Antiseptics and disinfectants. Chemotherapeutic drugs. General principles of acute poisoning treatment.
Prerequisites disciplines:
Molecular biology and medical genetics, biochemistry, physiology & microbiology
Objectives:
To learn the general principles of registration of recipes and drawing up recipes;
To learn to write out recipes on various medicinal forms;
To learn to choose the medicinal form and a way of application of a medical product;
To learn to count dozes and concentration of a medicine;
To generate representation about the general laws pharmacodynamics and pharmacokinetics of medicinal substances;
To learn to estimate opportunities of use and forecasting of influence of medical products for functions of bodies and systems of an organism;
To learn to choose medical products for suppression of ability to live of pathogenic microorganisms, the elementary, helminths.
Skills:
Calculation of dozes, the concentration of the drugs
Recipes on various medicinal forms;
Recipes on the basic vital medical products;
A choice of ways of introduction;
Educational methods:
Lectures: survey, problematic.
Practice: performance of practical works on a theme (experimental researches on animals, development of clinic-physiological techniques), work with the equipment, tables, atlases, decision of situation tasks, the performance of the test tasks, work in small groups, team-based learning (TBL), discussion of results of research, registration of the protocols.
Students’ individual work: work with the literature, preparation of presentations, and thematic abstracts.
Lectures: Topics & Number of Hours
Topic
Duration
Introduction. The general pharmacology.
2
Pharmacokinetics and pharmacodynamic medicinal substances
2
Cholinergic drugs. Cholinomimetics.`
2
Cholinergic drugs. Cholinoblockers.
2
Adrenergic drugs. Adrenomimetics.
2
Adrenergic drugs. Adrenoblockers.
2
The drugs influencing GABA-receptors (hypnotics).
2
The drugs influencing on opioid receptors (narcotic analgesics).
2
Anti-inflammatory drugs.
2
Anti-allergic drugs.
2
Antibiotics of beta-lactam structure.
2
Antibiotics of non-beta-lactam structure.
2
Synthetic antimicrobial drugs of different chemical structures.
2
Anti-tubercular drugs. Anti syphilis drugs.
2
Antifungal drugs.
2
Antiviral drugs.
2
Antiparasitic drugs.
2
The general principles of treatment of acute poisonings with drugs.
2
Practical & Classes: Topics & Number of Hours
Topic
Duration
The general receipts. Firm medicinal forms. Soft medicinal forms. Liquid medicinal forms. Medicinal forms for injections
3
The general pharmacology. Pharmacokinetics of drugs. Pharmacodynamic drugs.
3
The drugs influencing afferent innervations: local anesthetic drugs. Cholinergic drugs.
3
Adrenergic drugs.
3
Control lesson on the topic: General pharmacology & Drugs influencing a peripheral nervous system.
3
Narcotic analgesics. Non- narcotic analgesics.
3
Hypnotics.
3
Anticonvulsant, antiepileptic drugs. Anti Parkinson drugs.
3
Control lesson on the topic: Drugs influencing the central nervous system
3
Anti-inflammatory drugs
3
Anti-allergic drugs. The drugs influencing immune processes.
3
Control lesson on the topic: Drugs, influencing inflammatory and immune processes.
3
Antiseptics and disinfectants.
3
Antibiotics.
3
Antitubercular drugs. Antispirochete drugs.
3
Antifungal drugs. Antiviral drugs.
3
Antiprotozoal drugs. Anthelmintic drugs.
3
Control lesson on the topic: Chemotherapeutic drugs
A patient with a long history of cardiovascular disease develops worsening ventricular arrhythmias. Which of the following drugs is most likely to be the cause of the arrhythmia?
Quinidine
Propanolol
Dobutamine
Methyldopa
Viva
What drugs can decrease levels of thyroid-binding globulin? What drugs can increase levels of thyroid-binding globulin?
Situational tasks
A 20-yr-old unmarried woman presents with mild periorbital edema, mild proptosis, and a thyroid gland that is 1.5-fold enlarged. Her initial thyroid function tests reveal the following: free T4 (fT4), 2.3 ng/dl (normal, 0.8–1.8 ng/dl); T3, 250 ng/dl (normal, 80–180 ng/dl); and TSH, below 0.005 mU/liter (normal, 0.5–4.0 mU/liter). The 24-h radioiodine uptake is 40% (normal, 10–25%), and the scan shows a homogeneous pattern. Thyroid-stimulating immunoglobulin (TS) is positive.
What’s the most probable Dx?
Which drug should be used to treat this patient & why?
what is MOA of this drung?
For how long should she be treated to optimize the chances of remission?
Does the drug dose influence the chances of remission?
Scores
The score ranges from 5 to 1:
5 is “excellent” → Otlichno
4 is “good” → Khorosho
3 is “satisfactory” → Udovletvoritel’no
2 is “unsatisfactory” → Neudovletvoritel’no
Reference textbooks
Pharmacology: textbook. – 10th ed., Rev. and add. – Kharkevich D.A. 2010 .– 752 p.
Clinical pharmacology: textbook for universities / Ed. V.G. Kukesa. – 4th edition., Revised. and additional, – 2009. – 1056 p.
