Medical Criteria – N

Medical Criteria – N

NEUROFIBROMATOSIS (TYPE I; VON RECKLINGHAUSEN’S DISEASE)

• Diagnostic criteria include 2 or more of the following:

1. • More than 5 café-au-lait patches >1.5 cm in an adult or more than 5 café-au-lait macules >0.5 cm
   • in a child <5 yr
   • Axillary or inguinal freckling
   • Iris hamartomas (Lisch nodules)
   • Optic gliomas
   • Neurofibromas
   • distinctive bony lesion (sphenoid wing dysplasia or thinning of long bone cortex)
   • First degree relative with neurofibromatosis Type 1

NEUROLOGICALLY DETERMINED DEATH:

• Criteria of Diagnosis
  • Prerequisites: no CNS depressant drugs/neuromuscular blocking agents, no drug intoxication/ poisoning, temperature >32ºC, no electrolyte/acid-base/endocrine disturbance
  • Absent brainstem reflexes: pupillary light reflex, corneal reflexes, oculocephalic response, caloric responses (e.g., no deviation of eyes to irrigation of each ear with 50 cc of ice water – allow 1 min after injection, 5 min between sides), pharyngeal and tracheal reflexes, cough with tracheal suctioning, absent respiratory drive at PaCO2 ≥60 mmHg, ≥20 mmHg rise above baseline, and pH ≤7.28 (apnea test)

• • 2 evaluations separated by time, usually performed by two specialists (e.g., anaesthetist neurologist, neurosurgeon)
  • confirmatory testing: Flat EEG, absent perfusion assessed with cerebral angiogram

Also read:

1. Criteria in GPNotebook
2. Criteria in NICE
3. Criteria in Statpearls